The epigenetic signature for cardiac hypertrophy, which can progress to heart failure through an adaptive response of the myocardium to stress, is still poorly understood. The scientists at Humanitas Clinical and Research Center, Rozzano, Italy report on the genome-wide distribution of seven histone modifications in adult mouse cardiomyocytes subjected to a prohypertrophy stimulus in vivo. They found … Continue reading The Epigenetic Landscape is a Key Determinant of Gene Expression Reprogramming in Cardiac Hypertrophy
Dr. Eddy Bettermann MD 