Extra weight that you may have put on during the holidays could not only appear around your belly, but also add epigenetic tags to your DNA, suggests a new study. Having a high body mass index (BMI) was linked to additional methyl tags found at more than 200 areas on the genome, which affects gene expression and … Continue reading Being Overweight Adds Distinct Epigenetic Marks to DNA
The Epigenetic Landscape is a Key Determinant of Gene Expression Reprogramming in Cardiac Hypertrophy
The epigenetic signature for cardiac hypertrophy, which can progress to heart failure through an adaptive response of the myocardium to stress, is still poorly understood. The scientists at Humanitas Clinical and Research Center, Rozzano, Italy report on the genome-wide distribution of seven histone modifications in adult mouse cardiomyocytes subjected to a prohypertrophy stimulus in vivo. They found … Continue reading The Epigenetic Landscape is a Key Determinant of Gene Expression Reprogramming in Cardiac Hypertrophy
Dr. Eddy Bettermann MD 