For decades, we’ve known how important it is to receive proper nutrition during early stages of life. Nutritional experiences in the beginning of development can set the stage for many things, including body weight, and can even affect the risk of obesity as we get older. Recent research supports the idea that poor nutrition at the beginning of pregnancy or while a baby is nursing can be stored as molecular epigenetic “memory” on the child’s genome, potentially setting them up for metabolic diseases later in life.

Numerous studies reveal a connection between epigenetic marks, such as DNA methylation or histonemodification, and human obesity. New research in Nature Communications investigated a form of persistent epigenetic memory that may play a role in the developmental programming of obesity.

Cell Fuzion™ is an advanced antioxidant formula that protects cells against harmful free radicals and environmental toxins. It also supports healthy aging.As one of the most complex and fastest-growing areas of research in biological science, a wide array of studies delves into the nuances of epigenetic memory of nutrition. Researchers have demonstrated the inheritance and transmission of epigenetic marks across generations, but others have shown that the epigenetic transfer of nutrition memory ends before great-grandchildren. The contentious topic still requires further research, but numerous studies have begun to illuminate the ways in which early life choices might epigenetically influence our health and the health of our children later on.

Epigenetic research has shown that a son’s mental fitness could be influenced by his father’s diet even before the child is conceived and that the Mediterranean diet during pregnancy could epigenetically reduce a kid’s disease risk. Still, there is much more waiting to be uncovered.

A group of researchers from Tokyo Medical and Dental University (TMDU) add to the collection of studies on the persistence of epigenetic marks over time. Previously, they discovered that milk lipids which are released during lactation after a mother gives birth act as a ligand that activates the nuclear receptor PPARα, or peroxisome proliferator-activated receptor alpha.

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in regulating many biological processes, including the metabolism of lipids and glucose, overall energy homeostasis, and inflammatory responses. This particular transcription regulator, PPARα, plays a key role in liver fat metabolism and, in mice, is essential to preventing the liver from storing large amounts of fat.

By activating PPARα via milk lipid ligands, fatty-acid β-oxidation genes in the postnatal mouse liver become naturally demethylated. DNA methylation is a popular epigenetic mechanism known for switching genes off and reducing their expression. Administering a synthetic PPARα ligand (Wy) to mother mice during the perinatal period led to a greater reduction in DNA methylation of these genes in the liver of the mice offspring. The researchers confirmed that Wy was present in the breast milk of the mothers and ingested by her children.

With these findings in mind, the team utilized genome-wide DNA methylation analyses to explore whether the methylation status of PPARα target genes persists from early life to adulthood. Indeed, they found that a few of these genes which underwent ligand-activated PPARα-dependent DNA demethylation during the perinatal period persisted as the mice turned into adults.

Among the genes investigated, which the researchers referred to as “epigenetic memory genes”, they focused on fibroblast growth factor 21 (FGF21). FGF21 is a peptide hormone which plays a critical role in regulating energy homeostasis.

Koshi Hashimoto, MD, PhD, an Associate Professor in the Department of Preemptive Medicine and Metabolism at TMDU, explained: “We provide the first evidence that the PPARα-dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long-term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet-induced obesity.”

Cell Fuzion™ is an advanced antioxidant formula that protects cells against harmful free radicals and environmental toxins. It also supports healthy aging.Essentially, once DNA methylation status of FGF21 is established in early life, it could affect obesity in adulthood. The researchers suggest that the suckling period is a critical window of time for PPARα-dependent FGF21 demethylation to occur as a result of maternal environment.

Senior author Yoshihiro Ogawa, MD, PhD, said, “We propose that FGF21 methylation represents a form of epigenetic memory that persists into adulthood, and it may have a role in the developmental programming of obesity.”

With further research we can continue to unravel the mystery of nutritional epigenetic memory and get closer to understanding how early life experiences may set us up for positive or negative health outcomes much later in life.

Bailey Kirkpatrick

Source: Yuan, X., Ogawa, Y. et al. (2018). Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. Nature Communications, 9(1).

Reference: Tokyo Medical and Dental University. Epigenetic Modulation of Fgf21 Gene in Early-Life Ameliorates Adulthood Diet-Induced ObesityTMDU Press Release. 6 Mar 2018. Web.

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