Maintaining proper nutrition is a very important factor in living a long, healthy life. Foods that have little nutritional benefits have become easier to get our hands on, so the emphasis on proper nutritional health has become a fleeting priority for some people and their families. As a result, most individuals have inadvertently accepted the western diet, rich in empty carbs, red meats and saturated fats, as their everyday diet.
Diet can also impact a person’s epigenetics, and people can but themselves and the health of their future offspring in danger. In addition to the numerous ailments associated with a poor diet, young children who are obese may actually experience puberty earlier than their peers, and this process may be due to in part to epigenetic influence.
In a study published in Nature Communications, scientists from the Oregon Health & Science University set out to determine the correlation between diet, and early puberty in young girls. “Knowing how nutrition and specific molecules play a role in starting puberty early could one day help physicians prevent the condition in humans,” said Dr. Alejandro Lomniczi, the lead author of the study.
Over the last century or more, girls have been experiencing puberty at a much younger age. In the US, the average age of menarche (the beginning of menstruation) is now 12.5, preceded by puberty-induced body changes that occur on average 2-3 years earlier.
While the timing of puberty is highly dependent on genetic factors inherited from both parents, the alarming trend of advancement in timing indicates that more is at play than just DNA.
In a previous study, Dr. Lomniczi demonstrated that epigenetic mechanisms highly regulate female puberty. He identified that when a main puberty activating gene called Kiss1 is exposed to DNA methylation, puberty was more regularly induced.
In the current study, the researchers examined three different groups of rats: lean, average-sized, and overweight, focusing on the hypothalamus, which is known to regulate the pubertal process and reproductive development. The team aimed to figure out the differences in the expression of the Kiss1 gene in each of the differently nourished rats.
While the exact epigenetic pathways associated with nutrition’s impact on puberty are unknown, the team identified a histone deacetylase called SIRT1 as having an essential role in both conveying nutritional information to the brain and affecting the expression of the Kiss1 gene.
The scientists found that in malnourished rats there was a higher concentration of SIRT1 for a longer period of time, which delays expression of the Kiss1 gene, ultimately suspending the beginning of puberty. Contrastingly in overweight rats, there were decreased levels of SIRT1 in the hypothalamus, leading the rats to experience puberty earlier in their life.
Overall, the results from this study clearly identify SIRT1 as a regulatory enzyme that functions as a fundamental epigenetic channel linking obesity and nutritional status with changes in pubertal timing. Dr. Lomniczi plans to continue his research into the cause of early-onset puberty in females, considering among other things the roles of the circadian clock and endocrine disruptors.
Breast Cancer Risk
Understanding the relationship between nutrition and epigenetics is essential considering the influence of diet during early stages of mammary gland development on breast cancer risk. It’s hoped that this study and others which recognize the effects of diet will eventually lead to successful breast cancer prevention and treatment.
According to the Breast Cancer and the Environment Research Program, a girl who is overweight is more likely to enter puberty earlier than healthy girls of the same age. This can lead to a prolonged exposure to estrogen, which could elevate her risk for developing breast, uterine or ovarian cancer.
While breast cancer in pre-teen and teenage girls is rare, the results of this study help to emphasize the importance of maintaining a healthy diet, especially for girls at a young age in order to maximize disease prevention.
Source: Lomniczi A (2018) SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression Nature Communications 9, 4194
Reference: OHSU News. “Molecular link between body weight, early puberty identified” Oregon Health and Science University. 10 October 2018. Web.
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Dr Eddy Bettermann MD focus on Biological Medicine (Biologische Medizin), Darkfield Microscopy (Dunkelfeld Mikroskopie), Orthomolecular Medicine (Orthomolekulare Medizin), Ayurvedic Medicine (Ayurveda), Psychosomatic Medicine (Psychosomatische Medizin), raw food (Rohkost), fasting (Fasten): Our primary integrative medicine goal is the maintenance of your health and wellness, and we are committed to safe and effective healthcare. Our specialties include online integrative medicine education by alternative doctor: food and allergy management through the use of Integrative medical therapy, Environmental Medicine, General Family Medicine, Ayurveda, Panchakarma, Chronic Fatigue, ADHD, autism, Fibromyalgia, Yeast/Fungus related diseases – Candidacies, mercury dental replacement and detoxification, Natural Thyroid Replacement, Weight loss, Lyme Disease, Irritable Bowel Disease, Attention Deficit Disorder, Pervasive Developmental Disorders, Multiple Chemical Sensitivities, Addiction related programs, Intestinal Dysbiosis, as well as trigger point therapy using Neural Therapy. Dr. Eddy Bettermann MD, physician from Germany, consultant and teacher in biological medicine, especially dark field microscopy known as Live Blood Analysis in Thailand, Malaysia, Hon Kong, Singapore and the Philippines. But he lecture also in the USA, Canada and the U.A.E. He speaks english and german. https://dreddymd.com/2017/01/17/the-interactive-live-blood-cd-and-the-certified-training-live-blood-analysis-online-course/ https://dreddymd.com/courses/ https://dreddymd.com/2017/01/17/live-blood-microscopy-analysis-darkfield-course/ “Let thy Food be thy Medicine and thy Medicine be thy Food.” — Hippocrates Physician Member of the Medical Board at AOX Singapore, Medical Doctor at Nurse Mobile Clinic and Physician at DrEddy Clinic Our Mission: The mission of the Integrative Medicine is to search for the most effective treatments for patients by combining both conventional and alternative approaches that address all aspects of health and wellness – biological, psychological, social and spiritual. Biological Medicine is a big part of my work and so is Dark field Microscopy, what I use in my daily practice and what I teach more then 15 years in Asia and around the world: Live Blood Analysis in dark field based on Haematology. We utilize Live blood analysis since 2004, conventional as well as specialty laboratories for a thorough diagnostic work up of the disease in question. Our integrative medicine treatment regimens are especially unique and are tailored specifically to the individual needs of each patient. Our Mission: don’t harm, prevent, use food as medicine We are a reliable partner for integrative medicine in Medical Spa & Clinic Development and integrative medicine Education Training for alternative doctors – we bring different holistic approaches, like Integrative Medicine, Traditional Chinese Medicine and Ayurveda Medicine together. On your request we offer our service in your place as well. Heavy metal poisoning Heavy metal poisoning is much more common than most people realize, and if you’re thinking that it doesn’t apply to you because you haven’t been exposed to any, think again. If you’ve eaten fish regularly, had amalgam fillings, received vaccinations, drank contaminated water, or done industrial or agricultural work or pharmaceutical manufacturing, there’s a good chance that you have a fair amount of toxic metals in your system.. We are here to help and to educate! Wishing your health and happiness Dr Eddy Bettermann MD Protect you and your family from harmful radiation https://bit.ly/synergyscience-dreddymd More information about 5G and EMF: https://dreddymd.com/?s=5G+and+EMF View all posts by dreddymd