In this study, researchers from Kenya, Cameroon and Turkey evaluated the cytotoxicity of 11 naturally occurring compounds on human carcinoma cell lines and normal fibroblasts. Their findings were published in the Journal of Ayurveda and Integrative Medicine.
Cancer is a major health issue worldwide, and its treatment mainly relies on chemotherapy.- In search of natural anti-cancer agents, the researchers examined the potential of six phenolics (four chalcones and two flavanones) and five terpenoids (three clerodane and two trachylobane diterpenoids) using six human carcinoma cell lines and normal CRL2120 fibroblasts.
- They evaluated the cytotoxicity of the phytochemicals using the neutral red uptake (NR) assay and determined both the cell cycle stage and mitochondrial membrane potential (MMP) using flow cytometry.
- The researchers also used the caspase-Glo assay to detect caspase activation and measured reactive oxygen species (ROS) levels by spectrophotometry.
- The four chalcones and two trachylobane diterpenoids, as well as the chemo drug, doxorubicin, displayed IC50 values below 110 microMolar (uM) when tested on the six cancer cell lines.
- The IC50 values of the most active compounds were between 6.30 uM and 46.23 uM against breast adenocarcinoma MCF-7 cells and small lung cancer A549 cells, respectively, while the IC50 values of doxorubicin were between 0.07 uM and 1.01 uM against SPC212 and A549 cells, respectively.
- The chalcone 2?,4?-dihydroxy-6?-methoxychalcone also induced apoptosis in MCF-7 cells by increasing ROS production and MMP loss.
Based on these findings, the researchers concluded that the chalcones used in the study can be used to develop novel anti-cancer drugs against human carcinoma.
Read the full study at this link.
Evangelyn Rodriguez
Journal Reference:
Kuete V, Omosa LK, Midiwo JO, Karaosmanoglu O, Sivas H. Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells. Journal of Ayurveda and Integrative Medicine. 2019;10(3):178-184. DOI: 10.1016/j.jaim.2018.04.001


Related Posts
Like this:
Like Loading...
Related
Published by dreddymd
Dr Eddy Bettermann MD focus on Biological Medicine (Biologische Medizin), Darkfield Microscopy (Dunkelfeld Mikroskopie), Orthomolecular Medicine (Orthomolekulare Medizin), Ayurvedic Medicine (Ayurveda), Psychosomatic Medicine (Psychosomatische Medizin), raw food (Rohkost), fasting (Fasten):
Our primary integrative medicine goal is the maintenance of your health and wellness, and we are committed to safe and effective healthcare.
Our specialties include online integrative medicine education by alternative doctor: food and allergy management through the use of Integrative medical therapy, Environmental Medicine, General Family Medicine, Ayurveda, Panchakarma, Chronic Fatigue, ADHD, autism, Fibromyalgia, Yeast/Fungus related diseases – Candidacies, mercury dental replacement and detoxification, Natural Thyroid Replacement, Weight loss, Lyme Disease, Irritable Bowel Disease, Attention Deficit Disorder, Pervasive Developmental Disorders, Multiple Chemical Sensitivities, Addiction related programs, Intestinal Dysbiosis, as well as trigger point therapy using Neural Therapy.
Dr. Eddy Bettermann MD, physician from Germany, consultant and teacher in biological medicine, especially dark field microscopy known as Live Blood Analysis in Thailand, Malaysia, Hong Kong, Singapore and the Philippines. But he lecture also in the USA, Canada and the U.A.E. He speaks english and german.
https://dreddymd.com/2017/01/17/the-interactive-live-blood-cd-and-the-certified-training-live-blood-analysis-online-course/
https://dreddymd.com/courses/
https://dreddymd.com/2017/01/17/live-blood-microscopy-analysis-darkfield-course/
“Let thy Food be thy Medicine and thy Medicine be thy Food.” — Hippocrates
Physician Member of the Medical Board at AOX Singapore,
Medical Doctor at Nurse Mobile Clinic and
Physician at DrEddy Clinic
Our Mission:
The mission of the Integrative Medicine is to search for the most effective treatments for patients by combining both conventional and alternative approaches that address all aspects of health and wellness – biological, psychological, social and spiritual. Biological Medicine is a big part of my work and so is Dark field Microscopy, what I use in my daily practice and what I teach more then 15 years in Asia and around the world: Live Blood Analysis in dark field based on Haematology.
We utilize Live blood analysis since 2004, conventional as well as specialty laboratories for a thorough diagnostic work up of the disease in question. Our integrative medicine treatment regimens are especially unique and are tailored specifically to the individual needs of each patient.
Our Mission: don’t harm, prevent, use food as medicine
We are a reliable partner for integrative medicine in Medical Spa & Clinic Development and integrative medicine Education Training for alternative doctors – we bring different holistic approaches, like Integrative Medicine, Traditional Chinese Medicine and Ayurveda Medicine together. On your request we offer our service in your place as well.
Heavy metal poisoning
Heavy metal poisoning is much more common than most people realize, and if you’re thinking that it doesn’t apply to you because you haven’t been exposed to any, think again. If you’ve eaten fish regularly, had amalgam fillings, received vaccinations, drank contaminated water, or done industrial or agricultural work or pharmaceutical manufacturing, there’s a good chance that you have a fair amount of toxic metals in your system..
We are here to help and to educate!
Wishing your health and happiness
Dr Eddy Bettermann MD
Multimedia library https://bit.ly/2Wgqsd3
Protect you and your family from harmful radiation https://bit.ly/synergyscience-dreddymd
More information about 5G and EMF: https://dreddymd.com/?s=5G+and+EMF
Protocol https://amzn.to/2Nxsfql
View all posts by dreddymd