Severe platelet (thrombocyte) aggregation can be a serious finding. Platelet aggregation can contribute to cardio-vascular disease which is the number one cause of death in the
western world. Certainly additional laboratory work should be ordered to determine the cause of the platelet aggregation.


Several organic substances may promote platelet clumping which include collagen, ADP, the catecholamines, certain immune complexes and fatty acids. Diabetics and patients
with hypercholesterolemia usually demonstrate increased platelet aggregation which predisposes them to clotting disorders which can lead to vessel obstruction with thrombus and/or embolic formation. Cigarette smoking contributes to “hyperactive” platelet formation.

The following blood tests should be ordered to determine the cause of this ominous finding: Cholesterol, Triglycerides, HDL Cholesterol, Coagulation Time and Platelet Count.

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