Are doctors ready to save half a million people a year who die from Sepsis? We now have a game-changer for a condition that occurs in more than 1.5 million people a year in America, with a 28 percent to 50 percent fatality rate, according to the National Institutes of Health. Sepsis rates are even higher in third-world countries. Sepsis, a systematic inflammatory response to infection, is one of the most serious diseases in an ICU. Although comprehensive therapy has been developed for it, sepsis is still associated with high morbidity and mortality.
Science Daily reports, “With infectious diseases, it is often not the pathogen itself, but rather an excessive inflammatory immune response (sepsis) that contributes to the patient’s death, for instance as a result of organ damage. On intensive care units, sepsis is the second-most common cause of death worldwide. In patients with a severely compromised immune system specially, life-threatening candida fungal infections represent a high risk of sepsis.”
Dr. Paul Marik made headlines across the globe with a sepsis treatment he believes is saving lives, however he says he must “lie low” about the controversial treatment. Dr. Marik said the response by patients’ physicians has been about half and half, with some willing to try, and “the other half saying it’s complete and utter nonsense.” He is administering a common sense basic medicine approach that puts out cysteine storms with IV infusions of vitamin C, hydrocortisone and thiamine.
Vitamin C, Cancer and Oxidative Stress
A research team at the University of California, Berkeley found evidence that vitamin C does significantly reduce levels of oxidative stress, which is associated with a variety of chronic diseases, for people exposed to environmental tobacco smoke. Vitamin C also seems to ameliorate imidacloprid-induced oxidative damage by decreasing LPO (lipid peroxidation levels) and altering antioxidant defense systems in the liver.
Vitamin C is an important independent antioxidant with a key role in protecting cells from oxidative challenge and cell death from oxidative stress. When used in combination with other antioxidants like hydrogen, glutathione, magnesium, bicarbonate and iodine one can feel confident that such a protocol will address the most serious threats of sepsis as well as other life-threatening diseases.
IV vitamin C is a wonderful treatment when people are on the edge between life and death for it has the power to bring people back from the brink. Each of the medicinals mentioned above are heavy weight medicines useful in the direst medical circumstances when used correctly. Take vitamin D as an example, probably 200,000 units 50,000 at a time should be used for four days for sepsis patients. Vitamin D does some heavy lifting when administered intravenously to dialysis patients.
Hydrogen Outperforms Vitamin C
Sepsis, a multiple organ dysfunction syndrome, is the leading cause of death in critically ill patients. Hydrogen gas inhalation significantly improved the survival rate and organ damage of septic mice with moderate or severe cecal ligation and puncture, by reducing levels of early and late pro-inflammatory cytokines in serum and tissues.
Hydrogen’s protective effect on sepsis has been proved by biopsy, levels of inflammatory factors/anti-inflammatory factors, oxidative stress reductions, behavioral experiment, and other related indicators of organ function. Molecular hydrogen therapy is able to significantly reduce the release of inflammatory factors and oxidative stress injury thereby reducing damage of various organ functions that are so common with sepsis.
Hydrogen has protected organisms against polymicrobial sepsis injury, acute peritonitis injury both by reducing oxidative stress and via decreasing mass pro-inflammatory responses. It is also known that most viral induced tissue damage and discomfort are mainly caused by an inflammatory cytokine storm and oxidative stress rather than by the virus itself. Same goes for fungus infections that bring on sepsis.
Studies have shown that suppressing the cytokine storm and reducing oxidative stress can significantly alleviate the symptoms of influenza and other severe viral infections diseases. Medical scientists thus hypothesize that hydrogen-rich solution therapy to be a safe, reliable, and effective treatment for Multiple Organ Dysfunction Syndrome (MODS) induced by influenza and other viral infectious diseases.
Hydrogen is Safer
The main point here is not to stop administering C into these patients. Vitamin C has other healing life saving effects, as sufferers from Scurvy know. These properties are sorely needed in ICU patients. However, with hydrogen there is a greatly reduced need for high dosages of C not only because of the continuous nature of hydrogen inhalation, but also because hydrogen helps recycle Vitamin C.
This is important because medical scientists say, “Hydrogen is a safer gentler antioxidant that Vitamin C or E.” High levels of antioxidant vitamins C and E may have significant detrimental effects on the most sensitive cells (placental function), as reflected by decreased cell viability and secretion of hCG; and placental immunity, as reflected by increased production of TNF-a. Meanwhile hydrogen showed no such effects on cell proliferation and TNF-α expression, but it could affect the level of hCG, indicating hydrogen as a potential candidate of antioxidant in the management of preeclampsia (PE) should be further studied.
Cell viability was significantly suppressed by 500 μmol/L vitamins C and E (P < 0.05), but not by 500 μmol/L molecular hydrogen (P > 0.05). The expression of TNF-α was increased by 100 μmol/L vitamin C and 50 μmol/L vitamins E, separately or combined (P < 0.05), but not by molecular hydrogen (0-500 μmol/L), as validated by real-time RT-PCR. But the secretion of hCG was both inhibited by 50-500 μmol/L molecular hydrogen and high levels of vitamin C and E, separately or combined.
When we focus on Dr. Marik’s work it is impossible not to see the merits of his work and how many lives it can save. His hospital experimented with his protocol and saw a stunning mortality drop, but doctors are still skeptical because his hospitals study involved a small number of subjects, and because the study compared something at one point in time to a control group further back in time. However, medical institutions are taking this seriously enough to launch more than several studies, all of which will be too late to help the next million who will die of sepsis.
Published online in December 2016 in Chest, an American College of Chest Physicians medical journal. The study showed that in 47 patients with sepsis treated in Norfolk General’s ICU in 2016, four died, an 8 percent mortality rate. Of those four, none died of sepsis but rather the conditions that led to sepsis in the first place. The previous year, 19 of the hospital’s 47 septic patients died, a 40 percent rate. Dr. Marik has treated 700 patients with the protocol, and while some have died, it’s usually been because of the underlying disease, such as cancer, that led them to a septic state.
Is it too hard to listen to this doctor who is not only sharing his belief but the success of his treatments? Bending to the ignorance of modern medicine he says, “People who know about the treatment either are excited, or they think it’s snake oil medicine. It’s absolutely clear we need randomized controlled trials to validate this. It’s absolutely essential.”
He knows though this is not true, anyone who will pay the slightest attention will see it needs to be put into wide use now. Why wait to change if one is already failing miserably with what one is presently doing. From this moment onward, we can stare directly at the possibility of saving a million lives a year around the world with a safe and effective protocol for sepsis.
Saving Millions of Lives
We all know that the present day medical and governmental institutions will not see things in a way that will bring relief to these millions of patients and their families.
With sepsis it’s a matter of death for more than 500 thousand Americans a year. Most of these patients can be saved with hydrogen, oxygen, Vitamin C, D, CO2, administered with hydrocortisone and thiamine. Survival rates would be pushed higher with injectable selenium, IVs of sodium bicarbonate and injections of magnesium chloride. Many substances can be administered orally or as a gas for inhalation therapy.
Selenium is a strong antioxidant anti-inflammatory that can also be used. Protection against reperfusion injury, myocardial infarction, ischemic stroke, vascular surgery, are all alleviated with selenium injections as would cytokine storms provoked from out of control infections.
Inflammation is the activation of the immune system in response to infection, irritation, or injury. Characterized by an influx of white blood cells, redness, heat, swelling, pain, and dysfunction of the organs involved, inflammation has different names when it appears in different parts of the body. Our new protocol for sepsis works directly, not only on the life threatening oxidative stress but reduces and even removes that massive inflammation that is directly leads to organ failure.
The above essay is a chapter from my Hydrogen Medicine eBook.
- Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G. Shock. 2010 Jul; 34(1):90-7.
- Oxidative Medicine and Cellular Longevity. Volume 2016 (2016),
Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis
- Arch Gynecol Obstet. 2015 Aug;292(2):337-42. doi: 10.1007/s00404-015-3647-8. Epub 2015 Feb 14. Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.