A recent study has shown that following a western diet even before your child is born may lead to dysfunction of his or her autonomic nervous system via epigenetic changes. A western diet is high in saturated fats, red meats, and empty carbohydrates while being low in fresh fruit and vegetables, whole grains, seafood and poultry. Eating this way has been linked to many diseases, including hypertension, heart disease, diabetes, and obesity. Now, research suggests epigenetics may be involved in the impact this diet has on the human body, particularly in males.
Clinical studies have revealed that there is a high risk of developing type II diabetes if autonomic dysfunction is present. Autonomic dysfunction is a condition in which the autonomic nervous system does not work properly, affecting the function of the heart, bladder, intestine, and blood vessels, among other organs. Some symptoms include dizziness and fainting, sweating abnormalities, digestive difficulties, and sexual problems.
In a study published in Cell Molecular Neurobiology, researchers found that mice exposed to a high-fat, high-sugar diet for a period of time before giving birth led to epigenetic modifications of their offspring’s compensatory renin-angiotensin system, RAS. The renin-angiotensin system is a hormone system that regulates blood pressure, fluid retention, and vascular resistance.
Renin, which is released primarily by the kidneys, stimulates the formation of angiotensin in blood and tissue, which in turn stimulates the release of aldosterone from the adrenal cortex. Therapeutic manipulations of this pathway are very important in treating hypertension and heart failure, diseases linked to the consumption of a western diet.
In this study, researchers exposed male and female mice to either a regular diet or a high-fat high-sucrose diet until mating. Pregnant females continued their particular diet until the pups were weaned on the 21st day. After weaning, the offspring from both diet groups were fed a regular diet.
Several analyses were carried out using tissue samples of offspring, including DNA gene expression of ACE2 and AT1aR were also observed. The increase in gene expression ultimately translated into an increase in ACE2 activity.bisulfite sequencing, real-time PCR (RT-PCR), and ACE2 specific activity assays. Exposure to this high-fat and high-sugar diet in gestating and nursing dams resulted in a reduction of ACE2 methylation in major organs such as the brain, kidney, and cecum (a pouch in the large intestine) in her children. Moreover, changes in
ACE2 has been reported to play a critical role within the central nervous system in modulating autonomic function. Therefore, the increase in ACE2 activity is believed to alter autonomic function and, furthermore, potentially expose progeny to a higher sensitivity to cardiovascular and metabolic diseases.
The data from this study suggest that perinatal exposure to HFHSD resulted in epigenetic modifications of the compensatory brain RAS, potentially affecting plasticity of neuronal networks leading to autonomic dysfunction in the male offspring.
Recent studies suggest that epigenetic modifications, such as DNA methylation, play a critical role in the development of cardiovascular and metabolic diseases. This study demonstrates how a mother’s diet during pregnancy and prior to pregnancy may affect their offspring epigenetic modifications that can lead to the development of cardiovascular and metabolic diseases in the offspring’s life. The environment during pregnancy and early life is critical in shaping adults cardiovascular fitness and plasticity of the central nervous system. This suggests that we should consider the potential ramifications our diet may have not only on our own health but also on our children’s development.
Source: Mukerjee et al., Perinatal Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring. Cell Molecular Neurobiology. 2018. 38, p.233-242.
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Dr Eddy Bettermann MD focus on Biological Medicine (Biologische Medizin), Darkfield Microscopy (Dunkelfeld Mikroskopie), Orthomolecular Medicine (Orthomolekulare Medizin), Ayurvedic Medicine (Ayurveda), Psychosomatic Medicine (Psychosomatische Medizin), raw food (Rohkost), fasting (Fasten): Our primary integrative medicine goal is the maintenance of your health and wellness, and we are committed to safe and effective healthcare. Our specialties include online integrative medicine education by alternative doctor: food and allergy management through the use of Integrative medical therapy, Environmental Medicine, General Family Medicine, Ayurveda, Panchakarma, Chronic Fatigue, ADHD, autism, Fibromyalgia, Yeast/Fungus related diseases – Candidacies, mercury dental replacement and detoxification, Natural Thyroid Replacement, Weight loss, Lyme Disease, Irritable Bowel Disease, Attention Deficit Disorder, Pervasive Developmental Disorders, Multiple Chemical Sensitivities, Addiction related programs, Intestinal Dysbiosis, as well as trigger point therapy using Neural Therapy. Dr. Eddy Bettermann MD, physician from Germany, consultant and teacher in biological medicine, especially dark field microscopy known as Live Blood Analysis in Thailand, Malaysia, Hon Kong, Singapore and the Philippines. But he lecture also in the USA, Canada and the U.A.E. He speaks english and german. https://dreddymd.com/2017/01/17/the-interactive-live-blood-cd-and-the-certified-training-live-blood-analysis-online-course/ https://dreddymd.com/courses/ https://dreddymd.com/2017/01/17/live-blood-microscopy-analysis-darkfield-course/ “Let thy Food be thy Medicine and thy Medicine be thy Food.” — Hippocrates Physician Member of the Medical Board at AOX Singapore, Medical Doctor at Nurse Mobile Clinic and Physician at DrEddy Clinic Our Mission: The mission of the Integrative Medicine is to search for the most effective treatments for patients by combining both conventional and alternative approaches that address all aspects of health and wellness – biological, psychological, social and spiritual. Biological Medicine is a big part of my work and so is Dark field Microscopy, what I use in my daily practice and what I teach more then 15 years in Asia and around the world: Live Blood Analysis in dark field based on Haematology. We utilize Live blood analysis since 2004, conventional as well as specialty laboratories for a thorough diagnostic work up of the disease in question. Our integrative medicine treatment regimens are especially unique and are tailored specifically to the individual needs of each patient. Our Mission: don’t harm, prevent, use food as medicine We are a reliable partner for integrative medicine in Medical Spa & Clinic Development and integrative medicine Education Training for alternative doctors – we bring different holistic approaches, like Integrative Medicine, Traditional Chinese Medicine and Ayurveda Medicine together. On your request we offer our service in your place as well. Heavy metal poisoning Heavy metal poisoning is much more common than most people realize, and if you’re thinking that it doesn’t apply to you because you haven’t been exposed to any, think again. If you’ve eaten fish regularly, had amalgam fillings, received vaccinations, drank contaminated water, or done industrial or agricultural work or pharmaceutical manufacturing, there’s a good chance that you have a fair amount of toxic metals in your system.. We are here to help and to educate! Wishing your health and happiness Dr Eddy Bettermann MD Protect you and your family from harmful radiation https://bit.ly/synergyscience-dreddymd More information about 5G and EMF: https://dreddymd.com/?s=5G+and+EMF View all posts by dreddymd