Throughout our lives, all cells in our bodies experience a normal life cycle of growth, maturity, and death. During this time, our cells normally experience damage to DNA by normal functions of the metabolism, or exposure to certain environmental factors like UV light. Ordinarily, our body is able to repair the damage done to the DNA in order to restore healthy cell function.
The older we get, the more DNA damage we experience, and if damaged DNA is unable to be repaired, the cells become more susceptible to continued, erratic cell division, which often results in cancer. The cells of the body undergo a general wearing out process known as cell senescence, in which the cell ceases to replicate and is programmed for death. Senescence is a healthy, highly regulated process, and is crucial in the protection against tumor-growth.
It was previously considered by scientists that cancer development arises from rogue damaged cells that escape the natural cell death process and continue on to divide and grow. But scientists from the Johns Hopkins Kimmel Cancer Center have discovered that epigenetics could play a large role in how normal cells can develop into tumor-promoting cells.
In the study published in Cancer Cell, lead author Dr. Hariharan Easwaran and his research team dove into to the epigenetic modifications occurring during cellular senescence that could result in cancer development.
“Senescence is a very well-known, normal aging process that is actually an antitumor mechanism. It occurs when cells perceive an excess of DNA damage, when cells undergo too many cell divisions or when they experience cancer development-related stress. So it was puzzling to us how the senescence process could lead to the formation of tumors,” said Dr. Easwaran.
They focused their attention on DNA fibroblasts of human foreskin samples how it can disrupt normal cellular senescence, allowing the progression of tumor growth. DNA methylation is the epigenetic process that silences gene expression by adding methyl groups to the DNA sequence, making it an appropriate target for studying the healthy function of the cellular death process.patterns in the
In the experiment, these cells endured the laboratory process known as Weinberg’s classical transformation system, which converts normal, healthy cells to cancer cells by introducing genes that are known to promote tumor development. These newly transformed cells were then injected into mice so the research team could observe tumor progression. The researchers also allowed a second group of healthy fibroblast cells to mature into natural cellular senescence, and observed the DNA methylation patterns in both groups over time.
They discovered that the DNA methylation pattern in both senescent cells and transformed cells were initially similar, but the genes that were methylated along with the evolution of the cells were much different. Particularly, they found that DNA methylation in senescent cells was highly programmed, and had uniform epigenetic patterns among the different senescent groups. In transformed cells, they found that methylation patterns were highly erratic and random, and involved genes known to promote tumorigenesis.
In further experiments conducted by lead author Dr. Wenbing Xie, he found that he could not manipulate senescent cells into becoming cancer cells, confirming the protective nature that these cells have against tumor formation. In doing this, he also discovered a set of genes that are most vulnerable to cancer causing methylation, highlighting an important genomic region for future research.
The findings in this study suggest that hypermethylation to DNA promotor regions early on in cell development can hijack the senescence process and allow cancer cells to continually renew and multiply.
Dr. Stephen Baylin, one of the study’s coauthors believes their discovery is significant because it reveals the areas available to be treated to hopefully prevent future cancer development in aging cells: “Aging is probably the leading risk factor for most common cancers. Maybe you won’t find the Ponce de León Fountain of Youth, but if you could dampen down the risk of cancer for every decade you age, that could be huge.”
The scientists in this study hope that future research will focus on tissue-specific DNA methylation patterns in senescent and transformed cells in efforts to determine an individual’s risk for developing cancer as they age.
Source: Wenbing Xie (2018) DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk. Cancer Cell, 33 (2).
Reference: Johns Hopkins Medicine. “Cancer Risk Associated With Key Epigenetic Changes Occurring Through Normal Aging Process” Johns Hopkins Medicine News & Publications. 22 February 2018. Web.
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Dr Eddy Bettermann MD focus on Biological Medicine (Biologische Medizin), Darkfield Microscopy (Dunkelfeld Mikroskopie), Orthomolecular Medicine (Orthomolekulare Medizin), Ayurvedic Medicine (Ayurveda), Psychosomatic Medicine (Psychosomatische Medizin), raw food (Rohkost), fasting (Fasten): Our primary integrative medicine goal is the maintenance of your health and wellness, and we are committed to safe and effective healthcare. Our specialties include online integrative medicine education by alternative doctor: food and allergy management through the use of Integrative medical therapy, Environmental Medicine, General Family Medicine, Ayurveda, Panchakarma, Chronic Fatigue, ADHD, autism, Fibromyalgia, Yeast/Fungus related diseases – Candidacies, mercury dental replacement and detoxification, Natural Thyroid Replacement, Weight loss, Lyme Disease, Irritable Bowel Disease, Attention Deficit Disorder, Pervasive Developmental Disorders, Multiple Chemical Sensitivities, Addiction related programs, Intestinal Dysbiosis, as well as trigger point therapy using Neural Therapy. Dr. Eddy Bettermann MD, physician from Germany, consultant and teacher in biological medicine, especially dark field microscopy known as Live Blood Analysis in Thailand, Malaysia, Hon Kong, Singapore and the Philippines. But he lecture also in the USA, Canada and the U.A.E. He speaks english and german. https://dreddymd.com/2017/01/17/the-interactive-live-blood-cd-and-the-certified-training-live-blood-analysis-online-course/ https://dreddymd.com/courses/ https://dreddymd.com/2017/01/17/live-blood-microscopy-analysis-darkfield-course/ “Let thy Food be thy Medicine and thy Medicine be thy Food.” — Hippocrates Physician Member of the Medical Board at AOX Singapore, Medical Doctor at Nurse Mobile Clinic and Physician at DrEddy Clinic Our Mission: The mission of the Integrative Medicine is to search for the most effective treatments for patients by combining both conventional and alternative approaches that address all aspects of health and wellness – biological, psychological, social and spiritual. Biological Medicine is a big part of my work and so is Dark field Microscopy, what I use in my daily practice and what I teach more then 15 years in Asia and around the world: Live Blood Analysis in dark field based on Haematology. We utilize Live blood analysis since 2004, conventional as well as specialty laboratories for a thorough diagnostic work up of the disease in question. Our integrative medicine treatment regimens are especially unique and are tailored specifically to the individual needs of each patient. Our Mission: don’t harm, prevent, use food as medicine We are a reliable partner for integrative medicine in Medical Spa & Clinic Development and integrative medicine Education Training for alternative doctors – we bring different holistic approaches, like Integrative Medicine, Traditional Chinese Medicine and Ayurveda Medicine together. On your request we offer our service in your place as well. Heavy metal poisoning Heavy metal poisoning is much more common than most people realize, and if you’re thinking that it doesn’t apply to you because you haven’t been exposed to any, think again. If you’ve eaten fish regularly, had amalgam fillings, received vaccinations, drank contaminated water, or done industrial or agricultural work or pharmaceutical manufacturing, there’s a good chance that you have a fair amount of toxic metals in your system.. We are here to help and to educate! Wishing your health and happiness Dr Eddy Bettermann MD Protect you and your family from harmful radiation https://bit.ly/synergyscience-dreddymd More information about 5G and EMF: https://dreddymd.com/?s=5G+and+EMF View all posts by dreddymd