What we are going to look at in this chapter is a new concept in oxygen therapy, or what might be called oxygen manipulation; treatments that would alternate between oxygen deprivation and maximum oxygen saturation to stimulate the immune system, specifically, the white blood cells most responsible for battling cancer.
Researchers at UT Southwestern reported that increased oxygen coincides with a greater delay in tumor growth in an irradiated animal model. Oxygen is a switch hitter depending on its atomic states and so can act as a metabolic oxidizer, a more powerful immune oxidizer in singlet radical configuration, or as an “antioxidant” as it turns acidic protons to water when it mops-up after the process of respiration. Oxygen recharges pH buffers and conserves electrons.
Restoring oxygen levels to that of a normal cell makes the tumors three times more sensitive to treatment. Medical scientists know that oxygen works, it keeps us alive from moment to moment and comes in very handy when treating cancer. The only reason the mainstream of medicine does not embrace oxygen for cancer treatment is that the pharmaceutical companies cannot patent oxygen, which means there is no money in it.
Normal air contains 21 percent oxygen. Raising oxygen concentrations to 60 percent energized immune cells to shrink tumors in mice, researchers report in the March 4 Science Translational Medicine. About 40 percent of cancer-ridden mice put in an oxygen-rich environment survived 60 days or more. In contrast, mice that breathed normal air after getting an injection of lung-cancer cells died within about 30 days, say Stephen Hatfield of Northeastern University in Boston and colleagues.
Boosting oxygen in the air helped mice with cancer battle lung and breast tumors. A provocative study in mice suggests something as simple as breathing in extra oxygen might give immune cells a boost in attacking cancer. With the extra oxygen, “you remove the brake pedal” that cancer can put on tumour-fighting immune cells, said Michail Sitkovsky, director of the New England Inflammation and Tissue Protection Institute at Northeastern University.
Tumors grow rapidly as they suck up all the oxygen around them. Low oxygen causes tumors to release a chemical called adenosine, which makes immune cells sluggish and promotes tumor growth. Boosting oxygen counteracts adenosine and perks up immune cells called T cells and natural killer cells that shrink tumors. “The beauty is that oxygen per se is so well-tolerated,” added Dr. Holger Eltzschig, an anesthesiologist at the University of Colorado in Denver.
It turns out that cancer-fighting cells of the immune system can also improve their performance when starved of oxygen, which happens naturally at high altitudes or done at home at seal level with an add on device to an Exercise with Oxygen Therapy system (EWOT). In a study published in Cell Reports, Weizmann Institute of Science researchers have shown that immune system’s killer T cells destroy cancerous tumors much more effectively after being starved for oxygen. Oxygen-starved T cells proved much more effective at fighting the cancer.
This special form of EWOT, called Contrast Training, starts up with low oxygen setting (high altitude) and then when the body gets starved for oxygen one flips a switch and an avalanche of oxygen slams into the capillaries forcing oxygen into the cells. “Just as altitude training increases endurance in humans, so putting killer T cells through a ‘fitness regimen’ apparently toughens them up,” says Prof. Guy Shakhar of Weizmann’s Institute of Science Immunology Department.
Mountain climbers and endurance athletes are not the only ones to benefit from altitude training — that is, learning to perform well under low-oxygen conditions.
Eleven-time free-diving world champion Goran Colak during a bout of static apnea; timed breath-holding while immersed in water.
White blood cells respond strongly to altered breathing patterns. We can all voluntarily hold our breath depriving our cells of oxygen. They get hungry for O2 fast but some people, like Freedivers, who dive while holding their breath can hold their breath for over 10 minutes. Scientists at the Norwegian University of Science and Technology used blood samples from elite free-diving athletes to examine how white blood cells of the immune system responds to acute reduction in blood oxygen levels.
They measured total gene expression in the athletes’ white blood cells by a method called full genome microarray analysis. The analysis results were striking: the activity of more than 5000 genes changed in response to the simple effort of breath-holding. This is almost ¼ of all genes found in human cells.
NTNU said, “The most striking finding was a marked increase of the white blood cell type neutrophil granulocytes. These blood cells are programmed for rapid response when the body perceives attacks from intruders; the neutrophils are capable of killing invading cells simply by eating them. But they also have another interesting trait that emerges when oxygen levels drop: neutrophil granulocytes are evolutionary old-timers that stem from an era when the atmosphere contained less oxygen than now, and their modern offspring still prefer environments where the oxygen levels are low.”
We can do EWOT contrast training (costs about two thousand more than a regular EWOT system) and deprive the cells of oxygen and then flood the body’s cells with O2. This will enhance not only the above white cells who thrive on low O2 but also stimulate white blood cell types that use more oxygen – like lymphocytes – which were less active in blood drawn after the athletes held their breath. What we observed are likely to be traces of evolutionary history still embedded in our immune system, visible when oxygen levels change. The study was published in November 2016 in the journal Physiological Genomics.
Professor Ardenne wrote, “Because more than 80% of all cancer deaths are caused by metastases, development and evaluation of methods for fighting tumor dissemination should be major tasks of present cancer research. Formation of metastases is favored by both reduced numbers of immune cells in the bloodstream and impaired oxygen transport into tissues. These closely related signs often emerge concomitantly when the organism is endangered by circulating tumor cells released from the original tumor by therapeutic manipulations. From knowledge of these facts the O2-multistep immune-stimulation technique (EWOT) has been developed as a way of diminishing the risk of tumor spread. The process combines temporary elevation of the number of circulating immune cells with continuous improvement of oxygen transport into tissues.”
Otto Warburg established that lactic acid production is a fundamental property of cancer. It is carbon dioxide deficiency that impairs circulation and oxygen delivery to tissues. A lack of exercise leads to lower levels of carbon dioxide and this leads to lower levels of oxygen in the body. That is why cancer patients who exercise have a better prognosis and people stay healthier to begin with when they exercise and why EWOT is so wonderful and powerful in dealing with cancer.
Doctors are not interested in using oxygen to directly treat cancer. They do not want to look at the obvious. Hydrogen Medicine, when introduced (as separate treatment) into the oxygen/carbon dioxide matrix, will further increase the effectiveness of treatment. Hydrogen and CO2 hold the keys to successful oxygen therapy.
“In the presence of a large amount of carbon dioxide, the hemoglobin molecule changes its shape slightly, along with its electronic balance, in a way that favors the release of oxygen. The opposite happens in the presence of a high concentration of oxygen and a lower concentration of carbon dioxide,” writes Dr. Ray Peat.
If one wants to use oxygen successfully as a treatment for cancer then attention should be on increasing CO2 levels in the blood and tissues, which can be done with sodium bicarbonate, exercise and slow breathing practices. At the same time hydrogen water and inhalation of hydrogen gas should be employed.
Special Note: One in four adults worldwide doesn’t get enough exercise, putting “more than 1.4 billion adults at risk of developing or exacerbating diseases linked to inactivity,” a new study says. The study, which was conducted by researchers from the World Health Organization (WHO) and published in The Lancet Global Health, found that 27.5% of people across the globe do not meet the WHO’s physical activity guidelines of 75 minutes of vigorous exercise or 150 minutes of moderate exercise per week.
EWOT is a wonderful therapy for inactive patients because the oxygen part of the therapy assists with the exercise. Not enough exercise is a cause of cancer because it is a cause of CO2 deficiencies.
Dr. Mark Sircus
- Weizmann Institute of Science. September 18, 2017 Oxygen starvation could toughen up immune T cells for cancer immunotherapy, reports a team of investigators.
- Fundamentals of combating cancer metastasis by oxygen multistep immunostimulation processes.
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1985 May;17(1):47-65; http://www.ncbi.nlm.nih.gov/pubmed/3892251?ordinalpos=26&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum