enderleinThe concepts of pleomorphism and symbiosis are in the current perspective inseparable from the name of the great researcher and microbiologist,

Professor Dr. Günther Enderlein (1872-1968)

The basis for his work was the book by the French researcher A. Béchamp, titled “Microzymas”. It described that a microorganism can, under precisely determined preconditions, occur in diverse developmental stages and, especially also in diversified forms, without the loss of its specific characteristics. The microorganism may vary from the smallest rungs of electron microscopic magnitude up to the large, multinucleic and highly developed stages, such as of bacteria and fungi.

Moreover, Béchamp was able to prove that all animal and plant cells contain tiny particles which continue to live after the death of the organism and out of which microorganisms can develop. In this book, Béchamp laid the foundation for the concept of pleomorphism. The view that microorganisms can undergo a considerable variation in form, without losing their specific functions, stood and continues to stand diametrically opposed to the prevailing opinion of monomorphism, which admits only a single form and function to an organism. Naturally, that opinion has also resulted in a monomorphistic view of every disease process. Thus, in contrast to the opinion of Pasteur, that microorganisms simply exist without any developmental changes, Enderlein through intensive research came to the conclusion that the monomorphistic perspective of disease processes can no longer be maintained and had to be given up in favor of a pleomorphic perspective. He proved that every organism houses a primal plant germ in erythrocytes, which can very well become subject of a variation in form through exogenic influences.

Pleomorphism and Cyclogeny
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The opinion represented by pleomorphic bacteriologists of the fundamental changeability of forms holds the possibility for microorganisms to abruptly change from originally avirulent into potentially virulent conditions.

Enderlein devoted the bulk of his scientific work which stretched for more than 40 years, to the complex question of pleomorphism, symbiosis and cyclogeny of microorganisms. He published over 500 scientific articles. His chief work was titled Bacteria Cyclogeny, Berlin, 1925. (It is currently published by Semmelweis Verlag, Hoya, in the German language; it is available in English language from Pleomorphic Product Sales Inc.,). In this book he described in detail the changes and development of the parasite in its variable forms and its cycle.

This research was initiated by Enderlein in the year 1916, while he was working on typhoid. In blood using a darkfield microscope he observed mobile, tiniest living forms, named Spermits, which copulated with higher organized structures, whereafter the product of the copulation became suddenly invisible. Enderlein interpreted this as sexual processes, whereby tiniest, final products occurred, which are not visible to the eye of the light microscope. He named the symbiotic, primal plant germ in the erythrocyte Endobiont. This Endobiont lives in genuine symbiosis with the host organism, that is, with mutual benefits. Through outer factors, the Endobiont can multiply and develop – a process which can considerably disturb the symbiotic equilibrium. A healthy organism is capable of restoring the equilibrium. In this process, the more highly developed pathogenic germs are broken down into avirulent primitive forms through the copulation described by Enderlein. They leave the body through the natural organs of elimination.

The Nature of the Primal Germs and Symbiosis

However, the capacity for regenerating symbiosis is usually massively weakened through unhealthy lifestyles that are not in harmony with nature! Symbiosis is completed when the symbiont makes itself independent and becomes a parasite. In this, the Endobiont undergoes three basic phases: colloid-bacterium-fungus. This means, it develops from the apathogenic, non-mobile, tiniest albuminoid particle (Protit) – which is to be classified in size with the viruses (0.01 µm) – via the nonvirulent chondrit stage into the parasitic, pathogenic stages such as bacterium and fungus. According to Enderlein, they are not representing unchanging organisms that are independent of each other, but altogether they form a singular, common cycle, which has its origin in the colloidal, albuminoid substances that are contained inside of each particular cell.

Diseases of the Endobiosis Complex

Assisted by darkfield microscopy and using living blood, Enderlein was able to deliver clear proof of this vital, microbiological process in both its origin and cycle. As soon as this vital happening leaves a defined condition of equilibrium, all signs of parasitism occur, whereby out of the apathogenic symbionts (Protits and Chondrits)—with their enzymatic and metabolic active properties, they develop pathogenic microorganisms.

This explains, according to Enderlein, that all diseases of the Endobiosis complex are based on the upward development of the Endobiont into higher valenced, parasitic growth forms with their own metabolism that is harmful for body fluids. These disease processes are difficult to fathom, as they make themselves known in the beginning by functional disturbances in most diversified organs, such as, by headaches, high or low blood pressure, feeling poorly, unmotivated attitude, lack of appetite, drab complexion, coated tongue, wounds in the mouth, pimples, sores, hoarseness, catarrhs, ear noises, diarrhea, lowered capacity for seeing and hearing, depressions, weak concentration or poor memory.

Diseases, however, also indicate healing processes, which attempt to return a disturbed symbiosis to the original healthy condition. Whether the biological self-healing forces of the organism will win over the disease, or whether the symbiont is able to develop unchecked into a parasite, depends on the condition of the milieu in which the disturbance plays out. If the inner milieu is damaged through unhealthy nutrition and lifestyles, with their resultant disturbance of the acid-base equilibrium, through environmental toxins, through constant infections, or even through psychological depressions, then our self-healing forces are incapable of restoring our symbiotic equilibrium. Disease will manifest and damage the body. According to Enderlein, the milieu-conditioned cyclogenetic rise into higher stages of those microorganisms developed from the symbiont always determine the disease.

Foundations for Isopathic Therapy

Enderlein developed Isopathic Therapy with its specific biological remedies for all nonspecific, general symptoms that pertain to the Endobiosis Complex, based on the knowledge of the mutability of forms and the fact of the biological, and essential for life symbiosis between the mammal organism and the Endobiont. This unique perspective, at that time, distinguishes Enderlein as a pioneer of a modern, ecological world-view and puts monomorphism, which is still being taught, in question.

In his Bacteria Cyclogeny, Enderlein describes the development of the two mold fungi species Aspergillus niger van Tieghem (SA 4-20) and Mucor racemosus Fresen (SA 4-11), beginning from the primitive phases as tiniest colloidal albuminoid particles, via the bacterial phase, up to the fungal stage.

Both fungal species, which are likely obtained transplacentally, can occur as Endobionts in all their developmental stages within mammal bodies. Although their occurrence may be more or less frequent, they are to be seen as the cause of numerous ailments. The tubercular and paratubercular diseases, caused by pathogenic Aspergillus stages, do not occur quite as frequently as the disease processes more frequently caused by pathogenic Mucor phases arising from the Mucor symbiosis. The presence of the Endobiont in mammal organisms has been termed Endobiosis by Enderlein since 1946. By this are meant the apathogenic, low valanced phases of the Mucor racemosus Fresen (SA 4-11) (Protits, Symprotits, Chondrits, Fibrin). Fibrin is the highest developmental form of the Chondrit, before the Endobiont changes from the primitive phase into the bacterial phase (analogously to Siphonospora polymorpha v. Brehmer). In these lower valences, the symbiont supports the metabolism of the host organism, thus strengthening the defense. The higher the Endobiont rises in its developmental series, the more it increases in toxicity. The upward development of the Endobiont via the Chondrit form and higher is the cause for the endobiontic diseases, up to the death of the host organism. In the course of this process, the Endobiont is most likely partaking in the development of tumors. In the stages of precancerosis, one finds higher valenced Endobionts in the blood. According to Devrient, the cancer problem cannot be solved without regard to blood parasitism and polymorphism of the microorganisms. For Enderlein, “cancer is for the host organism a fermentation and decomposition condition, forced upon it by a parasitic fungus and its developmental forms.”

Because the Endobiont devours protein greedily, its upward development and the Endobiosis or congestion resulting from it are especially co-created through improper nutrition. Among these diseases belong vascular changes, pathological coagulatory processes, geloses, rheumatism, arthritis, spondylosis, tonsillitis, lymphogranulomatosis, diabetes, gout, tumors of every type (even those that are benign and their prestages), anemia, leukemia, cerebral sclerosis and paralyses.

The restriction of protein intake causes the return to lower phases, which then leave the body via the organs of excretion.

The Isopathic Preparations of the Fungal Phase

Another possibility for the breakdown of higher forms into lower stages is the exogenous supply of the so-called Chondritins in the quoted isopathic therapy. According to Enderlein, Chondritins are apathogenic, low developmental stages of diverse fungi, which can be either of a specific nature, as in the Mucor racemosus Fresen (SA 4-11) and Aspergillus niger von Tieghem (SA 4-20), or of an unspecific nature such as in Penicillium chrysogenum (SA 4-30) and Penicillium glabrum (SA 4-31). The specific Chondritins metabolize the virulent, parasitic microorganisms by copulation, thereby initiating their breakdown. The nonspecific Chondritins act as stimulating irritants by supporting the defensive capacity of the human organism through absorbing the ferments of foreign microbes.

Peter Schneider, Germany
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