Hepatoprotective activity of Limnophila repens (creeping marshweed) protects against paracetamol-induced toxicity

Researchers from India assessed the hepatoprotective activity of Limnophila repens (creeping marshweed) against paracetamol. They reported their findings in a study published in the International Journal of Green Pharmacy.

The liver plays a central role in all metabolic processes inside the body. It is responsible for metabolizing a number of xenobiotics.
Because of its function, the liver is more susceptible to the toxicity of chemical substances, particularly modern medications.
Hepatotoxicity is a huge problem often caused by drug metabolism. Liver disorders are quite difficult to diagnosis and have high fatality rates.
For their study, the researchers evaluated the hepatoprotective properties of the methanol extract of L. repens against paracetamol-induced hepatotoxicity.
To induce the condition in rats, they administered (2 g/kg) paracetamol to the animals for seven days.
Some of the rats were pretreated with 200 or 400 mg/kg/day of the extract for seven days prior to paracetamol treatment.
The researchers then analyzed blood samples to measure alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, cholesterol and proteins levels.
They also performed histopathological studies of liver samples.
The researchers reported that treatment with the methanol extract of L. repens considerably reduced the hepatotoxic effects of paracetamol and restored serum biochemical parameters to near normal levels.
Treatment with paracetamol caused loss of normal liver architecture and severe congestion of blood vessels, along with hepatic cell necrosis, vacuolization, plasma cells infiltration, degeneration of hepatocytes’ nuclei and liver fibrosis.
In contrast, the majority of liver cells pretreated with L. repens methanol extract remained normal.
The researchers also observed that samples pretreated with the highest dose of the extract had well-arranged hepatocytes at the recovery stage and showed no signs of necrosis.
Phytochemical analysis revealed that L. repens contains several bioactive compounds, such as:
- Flavonoids
- Volatile oils
- Alkaloids
- Tannins
- Phenolic compounds
- Phytosterols
- Glycoside

Based on these findings, the researchers concluded that L. repens has significant hepatoprotective properties, particularly against drug-induced toxicity.

Evangelyn Rodriguez

Journal Reference:

Venkateswarlu G, Ganapaty S. HEPATOPROTECTIVE ACTIVITY OF LIMNOPHILA REPENS AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN RATS. International Journal of Green Pharmacy. 2019;13(3):268-274. DOI: 10.22377/ijgp.v13i3.2598

Published by dreddymd

Dr Eddy Bettermann MD focus on Biological Medicine (Biologische Medizin) #Biological #Medicine #videos http://bit.ly/2LF3Ro3, Darkfield Microscopy (Dunkelfeld Mikroskopie), Orthomolecular Medicine (Orthomolekulare Medizin), Ayurvedic Medicine (Ayurveda), Psychosomatic Medicine (Psychosomatische Medizin), raw food (Rohkost), fasting (Fasten): Our primary integrative medicine goal is the maintenance of your health and wellness, and we are committed to safe and effective healthcare. Our specialties include online integrative medicine education by alternative doctor: food and allergy management through the use of Integrative medical therapy, Environmental Medicine, General Family Medicine, Ayurveda, Panchakarma, Chronic Fatigue, ADHD, autism, Fibromyalgia, Yeast/Fungus related diseases – Candidacies, mercury dental replacement and detoxification, Natural Thyroid Replacement, Weight loss, Lyme Disease, Irritable Bowel Disease, Attention Deficit Disorder, Pervasive Developmental Disorders, Multiple Chemical Sensitivities, Addiction related programs, Intestinal Dysbiosis, as well as trigger point therapy using Neural Therapy. Dr. Eddy Bettermann MD, physician from Germany, consultant and teacher in biological medicine, especially dark field microscopy known as Live Blood Analysis in Thailand, Malaysia, Hong Kong, Singapore and the Philippines. But he lecture also in the USA, Canada and the U.A.E. He speaks english and german. https://dreddymd.com/2017/01/17/the-interactive-live-blood-cd-and-the-certified-training-live-blood-analysis-online-course/ https://dreddymd.com/courses/ https://dreddymd.com/2017/01/17/live-blood-microscopy-analysis-darkfield-course/ “Let thy Food be thy Medicine and thy Medicine be thy Food.” — Hippocrates Physician Member of the Medical Board at AOX Singapore, Medical Doctor at Nurse Mobile Clinic and Physician at DrEddy Clinic Our Mission: The mission of the Integrative Medicine is to search for the most effective treatments for patients by combining both conventional and alternative approaches that address all aspects of health and wellness – biological, psychological, social and spiritual. Biological Medicine is a big part of my work and so is Dark field Microscopy, what I use in my daily practice and what I teach more then 15 years in Asia and around the world: Live Blood Analysis in dark field based on Haematology. We utilize Live blood analysis since 2004, conventional as well as specialty laboratories for a thorough diagnostic work up of the disease in question. Our integrative medicine treatment regimens are especially unique and are tailored specifically to the individual needs of each patient. Our Mission: don’t harm, prevent, use food as medicine We are a reliable partner for integrative medicine in Medical Spa & Clinic Development and integrative medicine Education Training for alternative doctors – we bring different holistic approaches, like Integrative Medicine, Traditional Chinese Medicine and Ayurveda Medicine together. On your request we offer our service in your place as well. Heavy metal poisoning Heavy metal poisoning is much more common than most people realize, and if you’re thinking that it doesn’t apply to you because you haven’t been exposed to any, think again. If you’ve eaten fish regularly, had amalgam fillings, received vaccinations, drank contaminated water, or done industrial or agricultural work or pharmaceutical manufacturing, there’s a good chance that you have a fair amount of toxic metals in your system.. We are here to help and to educate! Wishing your health and happiness Dr Eddy Bettermann MD Multimedia library https://bit.ly/2Wgqsd3 Protect you and your family from harmful radiation. DrEddyClinic is affiliate of Amazon and get commission for the products, which we recommend https://www.amazon.com/shop/dreddyclinic , same as GlobalHealing https://dreddymd.com/shop/supplements/ View all posts by dreddymd