When you study estrogen receptors, as Margaret Ritchie at St Andrews Medical School in Scotland has for years, you will be as excited as she is about the overall protection offered by H.R.T. Blocking this receptor with this safe natural substance that is 3000 times stronger than Genistein means far less Prostate cancer and Alzheimer’s for those lucky enough to have the Pueraria Mirifica in their daily diet. I, as a man, take one everyday, in the am or pm makes no difference, and with or without food.

Pueraria Mirifica is the active ingredient in the Herbal Remedy From Thailand (H.R.T. Plus) formula available only through Longevity Plus. This will be one of the most talked about breakthroughs in Anti-Aging and Bio-Identical Hormone therapy.

Since this herb does exhibit remarkable estrogenic properties, there will be many questions everyone should consider. However, the World Health Organization has clearly reported that the Northern Region of Thailand where this herb is part of the diet has the LOWEST INCIDENCE OF BREAST CANCER of any place they have reported on. There is also very low incidence of Osteoporosis and Alzheimer’s and Benign Prostatic Hypertrophy.

Since the potential for Breast enlargement would have significant financial implications, Pueraria Mirifica was studied for that potential commercial use. It was reported to be effective. The company in Thailand feels that the implications for women’s health are so important, they have attempted to distance themselves from that particular market although for a time they did supply a correctly formulated product with the real Mirestrol, which they have the exclusive test and knowledge to develop. Sold with a money-back guarantee, there was a very low return rate from the infomercial, which I believe was played in Canada.

There are many companies that do not have the real Pueraria Mirifica and because the potential market for breast enlargement creams is so large, and with over 12 varieties of Pueraria Mirifica known, there will be “knock-offs” claiming to provide breast enlargements that are NOT using the correct formula and/or make other formulation errors. That can easily lead to discrediting Pueraria Mirifica and lead to a complete loss of interest in further researching and developing the many other extremely important potential and exciting applications for this truly miracle herb. Definite research is now in progress that we are confident will document that this exact formula of Pueraria Mirifica will not induce cancer under any circumstances. Since it appears to be a Bio-mimic Estrogenic Adaptogen with SERM, Selective Estrogen Receptor Modulation activity, its future is far too vital for it to be exploited over its apparent potential to act as a breast enlargement product.

I am confident that this product will lower breast cancer incidence, as it has done in Northern Thailand and with currently over 2 million women now living with the diagnosis of breast cancer, this product takes on vital importance to the health of women and this “cosmetic” application for breast enlargement only can serve to confuse the market. I have found its topical application with Hyaluronic Acid and a special form of Vitamin C, as a wrinkle remover, in the NEW product, C-Perfection, to be extremely efficacious and that product is available now from Longevity Plus with the usual money back guarantee.

I am opposed to some other company researching and developing the product for applications from personal vaginal lubricant to possibly the breast enlargement market. I am simply concerned that since there are so many vital needs this product can fill, the breast enlargement application risks losing credibility for its many other, soon to be even further documented, many life saving applications. The Estrogen Receptor where it works so efficiently is involved in many health issues besides breast cancer, Osteoporosis, Alzheimer’s disease, Vaginal Mucosal atrophy, Prostate disease etc. We are inundated with ESTROGEN mimics from Pesticides etc. Finally it appears nature may have shown us a natural way to help overcome some of the many problems pollution is creating, with no downside!

Garry F. Gordon MD,DO,MD(H)

Pueraria mirifica (also known as Kwao Krua or Butea Superba) is a plant found in Thailand and Myanmar. According to Dr. Garry Gordon MD, who has been to Thailand for on-the-ground research, the region where this plant is grown is remarkable for its low rate of breast cancer and impressive longevity. He says Pueraria mirifica is 3000 times stronger than Genistein and “Makes Black Cohosh and Red Clover look like placebos.” Mirifica means “miracle” and it seems as if we have a miracle herb on our hands. You could call this new product HRT with a spin = herbal rejuvenation therapy or herbal remedy from Thailand!

The plant tuber contains phytoestrogens such as miroestrol, deoxymiroestrol, which are found only in Peuraria mirifica. They are much stronger than soy or red clover isoflavones, and are under investigation for possible use in hormone replacement therapy (in other words Big Pharma is trying to grab something from it that can be patented, to keep everyone else out). The pharmaceutically used variety is White Kwao Krua; the other ones are Black and Red Kwao Krua. The Thai government is supporting the commercial production of this product. They are backing research, which is starting to come down in floods.

Longevity Plus now produces Beyond HRT, which is Pueraria mirifica. It works really well for PMT and estrogen dominance, even where progesterone and lesser herbals, such a Black Cohosh, have failed. The price is right. I suggest you ladies get over there and purchase some. But do remember common sense; you will need to take the right nutritionals as well. NOTHING takes the place of quality nutrition.

Side effect or bonus?

Female Fuzion™ is a premier, herbal hormone balance formula for women that helps to support normal energy levels, increase vitality and regulate mood.But beware if you take it. You may end up with enlarged breasts! This is almost a side effect but Pueraria mirifica is now being promoted commercially for breast enhancement. You can buy it on eBay. Someone is even producing a chewing gum called B2Up (Bust-up Gum). Predictably, I suppose, it was a big hit in Japan, where girls long for (supposed) Western-style melons on their chest.

Surprisingly, all this is borne out by science. Tests carried out by Thailand’s Chulalongkorn University found Pueraria mirifica therapy was able to enhance breast size by up to 80%. Further tests carried out in England found that the plant had a beneficial effect on the skin, and hair, as well as the breasts.

The Problem. What Problem?

Well, it is an estrogen mimic and ought to make estrogen dominance worse. But the fact it is doesn’t. This blessed little herb is truly a gift to women tormented by their hormones (the majority). We may speculate that it acts at the estrogen receptor sites and has its special effect via that route, so displacing real estrogen, which is thus rendered more or less harmless.

It actually works as well as the drug Tamoxophen, to reduce risk of breast cancer cells proliferating. This would make sense if it displaces estrogen mimics. There is much more to research on this incredible story, which it appears should be in the diet of every women from adolescence on, so that we bring breast cancer rates down to what is proven to be the lowest in the world (Northern Thailand).

Men Too!

This is good news for men as well. Get the gum, guys! We know that male estrogen (di-hydro-testosterone) increases through time, while testosterone falls, due to aging, body fat, hormonal replacement, pesticides, nutritional deficiencies, prescription medications and excessive alcohol intake. In fact, studies have shown that the estrogen levels of the average 54-year-old man is higher than those of the average 59-year-old women! The end result is that these high levels of estrogen can cause reduced levels of testosterone, fatigue, loss of muscle tone, increased body fat, loss of libido and sexual function and an enlarged prostate.

Maybe Pueraeria mirifica should be in a man’s diet too.

But don’t suppose it will take the place of good diet, exercise, cutting down on alcohol and losing plenty of weight.

In addition, men are urged to consider:

Zinc, at least 15 mgms daily. Increases testosterone levels.

Chrysin (from the passion flower), which is well known to inhibit an enzyme called aromatase (Kellis JT Jr et al 1984). Aromatse converts testerone to male estrogen. Bodybuilders have used chrysin as a testosterone-boosting supplement because, by inhibiting the aromatase enzyme, less testosterone is converted into estrogen (our state governor Arnie can’t be wrong – can he?).

Carnitine. Both testosterone and carnitine improve sexual desire, sexual satisfaction, and nocturnal penile tumescence, but carnitine is more effective than testosterone in improving erectile function, nocturnal penile tumescence, orgasm, and general sexual well-being. Carnitine was better than testosterone at treating depression (Cavallini G et al 2004)

Cruciferous vegetables. Cruciferous vegetables, such as broccoli and cauliflower, contain isothiocyanates and glucosinolates, which act as antioxidants and potent inducers of phase 2 proteins believed to suppress prostate cancer formation (Kris-Etherton PM et al 2002; Talalay P et al 2001).

One extra tidbit, before we close: In males, estrogen is present in low concentrations in blood, but can be extraordinarily high in semen and as high as 250 picograms/ml in testicular fluids, which is higher than serum estradiol in the female.

Kwao Krua: General Information about Kwao Krua

Kwao krua is an indiginous Thai medicinal plant. Its tuber has been used in the folklore medicines for centuries,especially in the northern part of Thailand. There are two widely used Kwao Krua which are White Kwao Krua ( Pueraria mirifica, Airy Shaw & Suvatabhandhu ) and Red Kwao Krua ( Butea Superba ) . Kwao Krua is a big climber plant in the family of Papillionaceae. Its branch composes of 3 leaflets with glossy appearance similar to pea leaves. It has purplish blue flowers. The fruits are are flat pods. It is propagated by seeds. The tuberous root has brownish white skin. The flesh of White Kwao Krua tuberous root is white and red in Red Kwao Krua. The tuberous roots are varies in sizes. Its habitat is in rain forest at high altitude in Thailand especially In the northern part of Thailand.

Benefits of Pueraria mirifica

Pueraria mirifica has substantial health benefits. Its extracts are made by concentrating active ingredients from the rhizomes. The estrogenic substance in Pueraria mirifica is then isolated and tested on animals. Currently, there are hundreds of researches on application on humans and animals. In humans, Pueraria mirifica is used as tonics, supplementary foods, and ingredients for cosmetics. New application of Pueraria mirifica has also been introduced. With modern extraction technology, the dried roots are extracted and standardized into powder extract and solution extract which can be used in a number of industries. Typically, the health benefits of Pueraria mirifica are as follows:

– Maintains all female sex characteristics.
– Rejuvenates the body and keeps the body lively.
– Anti-menopausal syndrome.
– Firms breasts.
– Relieves menopausal disorder.
– Makes the skin beautifully young.
– Possesses anti-aging properties.
– Stimulates blood circulation.
– Boosts memory.
– Increases appetite.
– Improves complexion.
– Reduces wrinkles and freckles.
– Alleviates cataract problems.
– Nourishes skin condition, especially around the breasts.
– Combats premature graying of hair.
– Re-grows hair, strengthening and darkening existing ones.
– Increases energy and vigor leading to more reflexive bodily movement.
– Etc.

Pueraria mirifica is also extensively used in cosmetic productions. Main chemical substances in the plant—phytoestrogen and miroestrogen—can effectively stimulate the characteristics of women such as breast and hip enlargements. These two substances will induce the increasing of cell turgidity, not cell proliferation. The enlargement process will be continued at a level response before termination and the effect will be changed to breast firmness and then will still be maintained at the peak level. Pueraria mirifica can thus be produced into breast-firming cream, skin-nourishing cream, etc.

Recommended Dosage

Take about 1-5 mg per day.

Side Effects

– According to the studies, there are many side effects when taking Pueraria mirifica such as headache, vomiting, liver inflammation, and tumor.
– Taking Pueraria mirifica for 3-4 days consecutively, user may feel painful around the waist and joints.

Scientific and Toxicity Study of Pueraria mirifica

A series of studies involving breast cell lines and the activity of Pueraria mirifica in vitro have been performed by the Emory University School of Medicine in Atlanta, Georgia, USA, and the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, Bangkok, Thailand. These studies have shown that Pueraria mirifica root extract (Smith Naturals Co Ltd., Bangkok) has potent anti-estrogenic properties against aggressive cell cancer lines in vitro, especially the proliferative estrogen receptor-positive (ER+) breast cancer lines (T47-D, MCF-7, and ZR-75-1) obtained from the MD Anderson Cancer Institute (Texas) and the National Cancer Institute (NCI) at the U.S. National Institutes of Health (NIH).

Pueraria mirifica promotes fibroblasts in normal breast cells and inhibits estrogen-dependent breast cancer cells. Unpublished, 2001, Sawatsri, S., Juntayanee, B., Jitpatima, S., Boonnao, P., Kampoo, C., Ayuttaya, N., Wongyai, S. and Sidell, N.

According to the study conducted at the School of Medicine, Saint Mariane University, Tokyo, Japan by Kuramoshi, T. and Smitasiri, Y. about the preliminary study of Pueraria mirifica in Japanese females, 50 healthy menstruating volunteer females, ages 20 to 49, were given between 100 to 600 mg orally of Pueraria mirifica root powder daily as capsules for 7 days, two weeks after menstruation. No reports of abnormally heavy, severe, or missed menstruation were recorded.

Animal Test: There were reports during the year 1960-61 from the British researchers to test the effects of miroestrol; the key chemical from this herb in the ovariectomized and the premature female rats. The results showed the estrogenic effects of this chemical. It implied that the sythetic estrogen or animal estrogen or even human estrogen could be substituted by this chemical.

Human Test: Miroestrol has also been tested in human and was reported in 1961 as a potent estrogen effect. The Thai medical doctor has tested the crude extract in the patients in the year 1941. The result also showed the promising application of this herb.

Skin Test: Six female albino rats were hair cut and injected with 0.1% of Pueraria mirifica extract. The test was completed and showed no allergic to skin. It implied that the dermal diffsion did not cause any dermal irritation to the skin. Thus, the Pueraria mirifica extract can be presented in the cosmetics without any allergic effect.

Research and Study on Pueraria mirifica

It has been revealed recently that Pueraria mirifica is safe to be used in human in certain dosage as well as consumption period. The researcher has been conducting a series of researches covering the chemical analysis, tissue culture, mass propagation, cultivar improvement, production, product development and testing and so on for 9 years. The result shows that the selected Pueraria mirifica contains very high isoflavone content and shows high antimutagenic effects as well as high killing effects to human mammary cancer cell line. Nowadays, nutritionists recommend the consumer to consume isoflavone regularly for the purpose of cancer protection normally found on post-menopausal and people who have hormone imbalance.

The Benefits of Miroestrol and Its Derivatives in Pueraria mirifica

Miroestrol and its derivatives are also precious chemicals in the white kwao kreu which promote estrogenic and mammogenic effects to various tissues such as breast enlargement or breast tissue reformation.

The Differences between Soya and Pueraria mirifica

Soya, the western health food products, contains lower amount of phytoestrogens especially there is no miroestrol and its derivatives. Their benefit to the body is far less than that of Pueraria mirifica. The researches confirm that these chemicals are potent anti-breast cancer, anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome.

Applications of Pueraria mirifica

Pueraria extract is a natural specialty product designed to help promote normal healthy sexual function and rejuvenescence in women. Pueraria mirifica imitates the human estrogen that is a natural body compound affecting the human body, including growth and maintenance of all female sex characteristics. Therefore, when Pueraria mirifica is applied it will help replace the lost estrogen and rejuvenate the specific area.

Local women and rural communities in Thailand have used Pueraria mirifica effectively as a traditional medicine for over hundred of years. Today, extracts from the root of Pueraria mirifica are claimed by mainstream medical researchers, medical physicians and herbalists as a “Fountain of Youth” that manifest properties contributory to rejuvenescence – firms breasts, regrows hair / strengthens and darkens existing ones, helps improve complexion and reverses wrinkle effects, alleviates cataract problems, increases energy and vigor leading to more reflexive bodily movements, etc.

Although phytoestrogen can also be found in other natural products such as soybeans and bean curt, phytoestrogen in Pueraria mirifica is far greater than that in other products. Apart from daidzin, genistin, and daidzein that are usually found in soybeans, Pueraria mirifica also contains miroestrol which is believed to have 3,000 times of potency more than soybeans in promoting estrogenic activities.

Pueraria mirifica and Women

Most women are very concerned about aging, particularly the effects brought about by the aging process. At a certain age, the body experiences dramatic changes: the body’s systems and its functions begin to decelerate and the immune system weakens. For the average woman, menstruation cycles end at 48-50 years of age when the reproductive system stop or slow down functioning. Moreover, it is a fact that women whom no longer menstruate are further troubled by the adverse effects of lower levels of estrogen in the body. Estrogen helps to control the production of free radicals (free radicals are perceived as being harmful for the body because it accelerates degeneration of bodily organs), and therefore lack of estrogen will induce production of free radicals. Consequently, menopausal women will experience both psychological and physiological changes. Psychological changes range from anxiety, tension and nervousness to chronic depression. Whereas the physiological affects include hot flushes, fatigue and insomnia to more severe conditions as bone loss, balding and degeneration of the reproductive area. Pueraria mirifica contains substances that can effectively cope with these problems.

Nat Prod. 2000 Feb;63(2):173-5.
Identification of deoxymiroestrol as the actual rejuvenating principle of “Kwao Keur”, Pueraria mirifica. The known miroestrol may be an artifact.
Chansakaow S, Ishikawa T, Seki H, Sekine (nee Yoshizawa) K, Okada M, Chaichantipyuth C.
Faculty of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.

Miroestrol has been isolated previously as an active principle from “Kwao Keur” (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol. The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.

Planta Med. 2000 Aug;66(6):572-5.
Isoflavonoids from Pueraria mirifica and their estrogenic activity.
Chansakaow S, Ishikawa T, Sekine K, Okada M, Higuchi Y, Kudo M, Chaichantipyuth C.

Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isolated from the tuberous root of Pueraria mirifica (Leguminosae). The structure of puemiricarpene was determined by spectroscopic means. Estrogenic activity of the isolated isoflavonoids was tested using MCF-7 human breast cancer cells. Moderate activity was observed for kwakhurin, a prenylated isoflavonoid.

J Vet Sci. 2002 Dec;3(4):273-7.
Requirement of metabolic activation for estrogenic activity of Pueraria mirifica.
Lee YS, Park JS, Cho SD, Son JK, Cherdshewasart W, Kang KS.
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, San 56-1, Shilim-dong, Kwanak-gu, Seoul 151-742, Korea.

A wide range of chemicals derived from plant and human-made xenobiotics are reported to have hormonal activities. The present study was performed to examine the estrogenic effect of Kwao Keur, Pueraria mirifica (PM), that has been used as a rejuvenating folk medicine in Thailand, using recombinant yeast, MCF-7 cell proliferation and HepG2 cell transient transfection assay. In recombinant yeast assay, 0.025, 0.25, 2.5, 25, 2.5 x 10(2), 2.5 x 10(3), 2.5 x 10(4) ng/ml concentrations of PM did not show any estrogenic activities, while 10(-9) of 17 beta-estradiol (positive control) showed high estrogenic activity. Estrogenic activities were induced at 2.5 ng/ml to 25 microg/ml concentrations of PM in a dose-dependent manner on MCF-7 cells and the estrogenic effect of PM was blocked by tamoxifen treatment, a well-known anti-estrogen. PM also showed estrogenic effect on human hepatoma cell line, HepG2 cells, containing estrogen receptor and luciferase reporter gene. Taken together, PM in itself may have no estrogenicity in yeast system, but it has estrogenicity in MCF-7 & HepG2 cells that have human metabolic enzymes. The results indicated that PM may require metabolic activation for estrogenic activity.

Press Release about Pueraria mirifica

Breast Enlargement: The Thai Herb

In Thailand they have an herbal plant that is supposed to help in growing your breasts, and they are afraid it may fall into foreign hands.

The Pueraria mirifica root has been popular with Thai women for decades. The plant is supposed to have an estrogenic effect and can enlarge the breasts and hips of women. How much depends from woman to woman, they claim. And, of course, several Japanese firms are interested.

The Japanese have moved in, and the Germans and even the US firms are going to after the plant. Thailand’s government is considering a ban on the plant’s export to prevent piracy to foreign countries.

Indeed, if estrogenic, the herb isn’t going to be useful because you can’t just give people estrogens in high enough doses to increase their breasts. It is not that simple.
Source: The Bangkok Post Oct, 19 1998.

Experts Want New Bill Passed Soon: Concern over Piracy by Foreign Companies
At a recent meeting on the matter, Dr. Wichai Cherdshewasart of Chulalongkorn University’s Faculty of Science urged the Food and Drug Administration to immediately approve the registration of two drugs made of white kwao kreu (Pueraria mirifica) and red kwao kreu (Butea superba).

White kwao kreu hit the new headlines last year when doctors identified that it enlarged the breasts of a monkey regularly consumed the herb. White kwao kreu is believed to contain the female hormone estrogen while the red kwao kreu is believed to stimulate the female hormone.

The prompt registration of the herb was urged by the Chulalongkorn University researches, for fear that patent would be taken advantage of by foreigners who would then export the finished product made from Thai herbs for sales in Thailand at a much higher price.

Associate Prof. Yuthana Samitasiri of Nakhon Ratchasima’s Suranari Technology University said some 40 tons of kwao krue is trucked from Northern Province of Thailand to south China and Japan every month.

Most of the kwao kreu processed by the Japanese are made into medicines and cosmetics commonly used improving the skin, hair and firming breasts.

Food and Drug Administration secretary-general Mongkhol Na Songkhla said the FDA did not object to the registration of products made from kwao kreu forwarded by Dr. Wichai of Chulalongkorn University, but it still waits more research information to prove that it is scientifically safe.
Androtrex® is a vegan-friendly, herbal formula specially crafted to help support normal hormone balance in men and naturally strenghten male vitality.
Dr. Wichai said that what is of utmost concern is that the herbs are not only being exported to Asian countries, but also being shipped to Germany from China. He said state authorities should take immediate action in controlling the export of the Thai herb by adding it to the list of seven protective plants that are not allowed to be taken out of the country.

Institution of Traditional Thai Medicine director Pennapha Subcharoen however cautioned that Thailand may not be able to totally claim the plant as a Thai plant because it is also grown in neighboring countries like Burma and Laos.

Studies done in 1998 on the consumption of white kwao kreu in subjects aged 20-45 showed various benefits. It confirmed not only the ancient beliefs but also the benefits to the skin of breasts and the possibility of helping menopausal women. During tests on approximately 100 women, no adverse effects were observed.
Source: Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand

Medical Reports on the Effectiveness of Phytoestrogens

February 4, 2002-As reported on NEWS NET 5: Cleveland, Ohio, March 12, 1999-There is new information that suggests an herbal plant will enhance your breasts. News Channel 5 reports new finding show if women take an herb called Pueraria mirifica, it will increase their breast size.

“The root is presumed to contain substances that might have an effect on glands”, said medicinal plant expert Tyler, Ph.D.
“The herb is so popular that demand is outweighing supply”

References (8)
  1. Bounds DG, Pope GS. Light-absorption and chemical properties of miroestrol, the oestrogenic substance of Pueraria mirifica. J Chem Soc 1960: 3696-705.
  2. Cain JC. Miroestrol: an oestrogenic from the plant Pueraria mirifica. Nature 1960; 188: 774-7.[3] Hayodom M. Constituents of the tuberous roots of Pueraria mirifica. [Master Thesis Department of Chemistry]. Bangkok: Graduate school Chulalongkorn University; 1971.
  3. Ingham JL, Tahara S, Dziedzic SZ. Coumestans from the roots of Pueraria mirifica. Z Naturforsch Ser C 1988; 43 (1/2): 5-10.
  4. Jones HEH, Pope GS. A method for the isolation of miroestrol from Pueraria mirifica. J Endocrinol 1961; 22: 303-12.
  5. Kashemsanta L, Suvatabandhu K, Airy Shaw AK. A new species of Pueraria (Leguminosae) from Thailand, yielding an oestrogenic principle. Kew Bull 1952; 4: 549-51.
  6. Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstetrics & Gynecology 1996; 87 (5): 897-904.
  7. Tahara S, Ibrahim RK. Prenylated isoflavonoids-an update. Phytochemistry 1995; 38 (5): 1073-94.
  8. Wang C, Kurzer MS. Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 1997; 28 (3): 236-47.

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